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Medicxi

GBUSDEFRNLCHCNSGBio/PharmaHealthtechDeep Tech

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Investment thesis

Medicxi is a leading European life sciences venture capital firm with a mission to create and invest in companies across the full drug development continuum. The firm pioneered the 'asset-centric' investment model — backing biotechnology companies built around a single, highly validated drug asset with a clear product vision to fulfil an unmet medical need — rather than diversified platform companies. This capital-efficient approach concentrates diversification at the portfolio level, not within individual companies, enabling faster, leaner paths to clinical proof-of-concept and pharma partnership or acquisition. Medicxi invests in early- and late-stage therapeutics, both by creating new companies from scratch alongside drug hunters and entrepreneurs, and by investing in existing companies at all stages of development that align with its asset-centric value creation strategy.

Notable quotes

Medicxi's longstanding success has been founded on its unique ties to leading global pharmaceutical companies and its world-class team of drug hunters and clinicians. The new €500 million fund will enable Medicxi to provide the critical capital, expertise and experience to deliver transformative therapies for patients.

Francesco De Rubertis · Medicxi Announces €500 Million Fund V press release, medicxi.com · 2025-11-14

Medicxi's differentiated, capital-efficient investment strategy is rapidly scaling and we have now raised six funds in the last 10 years, totalling over €2.0 billion. We are extremely grateful for the support that we have received from our existing and new limited partners, and we are excited to continue investing in cutting-edge science and accelerating the discovery of life-changing medicines for patients.

Giovanni Mariggi · Medicxi Announces €500 Million Fund V press release, medicxi.com · 2025-11-14

Our mission is to support the innovative genius of entrepreneurs by providing the critical capital, expertise and experience that form the all-important 'bridge' to pharma. This new fund consolidates Medicxi's position as a key operating platform for scientific entrepreneurs and drug hunters and is deliberately sized for our investment model.

Francesco De Rubertis · Medicxi Announces $400m Medicxi IV press release, medicxi.com · 2023-01-01

Recent investments

CompanyRoundSizeDate
Altesa BioSciencesSeries B$75m2026-02-19
D3 BioSeries B$108m2025-12-10
FORE BiotherapeuticsSeries D$38m2025-05-06
Curevo VaccineSeries B$110m2024-01-01
Centessa PharmaceuticalsSeries A$250m2021-02-16
Merus N.V.Series B+
VaxcyteSeries B+
AbivaxSeries B+
ViceBioSeed
Aura BiosciencesSeries B+

Frequent co-investors

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