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Twin Path Ventures

GBAI/MLDeep TechHealthtechBio/PharmaB2B SaaSFintechEnterpriseClimate

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Investment thesis

Twin Path Ventures is a London-based pre-seed and seed fund dedicated exclusively to AI-first startups. The firm backs highly technical, intelligent, and committed teams bringing a proprietary deep-tech advance to an industry they know, with a belief that 'doing AI well is still a deep tech / engineering challenge.' Twin Path invests in state-of-the-art AI research and development, targeting revolutionary solutions to address global challenges, and sources deals primarily from leading UK academic institutions and accelerators. The fund's unique structure blends SEIS, EIS, and non-tax capital, enabling tax-efficient returns for LPs. Twin Path backs founders who are 'super ambitious' and aims for both IPO-track outcomes and earlier exits within 3–5 years for highly technical founders who prove commercial traction. The fund does not need unicorns to succeed — it succeeds by backing founders that can get exits. Backed by the British Business Bank, Twin Path invests approximately £10M per year into 12–15 companies, prioritising opportunities across all nations and regions of the UK.

Notable quotes

This partnership with British Business Investments marks a significant milestone for Twin Path Ventures as we continue to build on our mission of empowering AI innovators.

John Spindler · British Business Bank press release / CBInsights · 2025-02-20

Our fund does not need to succeed by backing unicorns. Our fund succeeds by backing founders that can get exits.

John Spindler · twinpath.vc website

WholeSum brings scientific rigour and automation to a universal problem. This is foundational infrastructure for how qualitative evidence will be generated and trusted in the future.

John Spindler · WholeSum pre-seed press release, uktechnews.info · 2026-01-05

Team

John Spindler

Co-founding Partner / General Partner

AI/MLDeep TechEnterpriseB2B SaaS

Nick Slater

Partner

AI/MLDeep TechClimateConsumer

Katie Lockwood

Co-founding Partner

HealthtechBio/PharmaDeep TechAI/ML

Isabelle O'Keeffe

Team Member

Deep TechAI/ML

Athena Karsa

Team Member

Deep TechAI/ML

Recent investments

CompanyRoundSizeDate
WholeSumPre-seed$921k2026-01-05
Aisthesis MedicalPre-seed$1m2025-10-01
TrismikPre-seed$3m2025-12-01
Sention TechnologiesSeed$5m2025-05-21
AMPLY DiscoverySeed$2m2025-05-01
Sagittal AIPre-seed$2m2025-04-07
InsureVisionSeed$3m2025-03-10

Frequent co-investors

VC firmDeals together
XTX Ventures2
Fuel Ventures1
SineWave Ventures1
Venture Science1
TECS Capital1
Doral Energy-Tech Ventures1
Endgame Capital1
Rethink Ventures1

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