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Xontogeny is a Boston-based life sciences accelerator that collaborates with entrepreneurs, scientific founders, and first-time CEOs to drive the successful development of technologies enabling new treatment options for patients with serious disease. It provides seed investment capital and hands-on operational support across therapeutics, diagnostics, and devices, with the singular goal of shepherding each program through a compelling clinical proof-of-concept study. In partnership with Perceptive Advisors, Xontogeny manages the Perceptive Xontogeny Venture Funds (over $700M AUM across two funds), which lead or co-lead Series A financings in the range of $10–50M and participate in select Series B and growth-stage rounds. The strategy spans biotechnology, medtech, digital health, and life sciences tools/services, with a data-driven focus on advancing differentiated technologies from preclinical stage through clinical proof-of-concept across North America.
Notable quotes
“We have been impressed with the execution of the PXV Fund strategy and how quickly we found quality opportunities for investment. To further strengthen our efforts, Chris has successfully expanded the Xontogeny team to serve as Perceptive's early-stage venture arm, which is fully integrated with the Perceptive investment team.”
“We're helping founders build companies around life-saving technologies while showing that capital can be deployed more efficiently to benefit both founders and investors.”
“The PXV Fund will benefit from the Xontogeny model and its ability to seed finance, incubate and de-risk early-stage technologies by providing proven operational expertise, a more capital-efficient structure, and a strong partnership in advising and mentoring entrepreneurs and scientific founders.”
Team
Fred Callori
Senior Partner
Gianna Hoffman-Luca, Ph.D.
Partner
Takeru Furuya, Ph.D.
Principal
Thien Nguyen, Ph.D.
Senior Associate
Jayanth Batchu
Senior Associate / EIR
Recent investments
| Company | Round | Size | Date |
|---|---|---|---|
| Crystalys Therapeutics | Series A | $205m | 2025-09-30 |
| Merida Biosciences | Series A | $121m | 2025-04-08 |
| Marea Therapeutics | Series A | $190m | 2024-06-18 |
| Neurosterix | Series A | $63m | 2024-04-03 |
| CARGO Therapeutics | Series A | $200m | 2023-03-01 |
| Apogee Therapeutics | Series B | $169m | 2023-01-15 |
| TORL BioTherapeutics | Series B | $158m | 2023-04-13 |
| Avalyn Pharma | Series C | $175m | 2023-09-27 |
| Forge Biologics | Series B | $120m | 2021-04-29 |
| Galvanize Therapeutics | Series C | $100m | 2025-09-03 |
Frequent co-investors
| VC firm | Deals together |
|---|---|
| Third Rock Ventures | 4 |
| RTW Investments | 3 |
| SR One | 3 |
| RA Capital Management | 2 |
| Bain Capital Life Sciences | 2 |
| Wellington Management | 2 |
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