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Xontogeny

VC

USCACHBio/PharmaHealthtechDeep TechAI/ML

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Investment thesis

Xontogeny is a Boston-based life sciences accelerator that collaborates with entrepreneurs, scientific founders, and first-time CEOs to drive the successful development of technologies enabling new treatment options for patients with serious disease. It provides seed investment capital and hands-on operational support across therapeutics, diagnostics, and devices, with the singular goal of shepherding each program through a compelling clinical proof-of-concept study. In partnership with Perceptive Advisors, Xontogeny manages the Perceptive Xontogeny Venture Funds (over $700M AUM across two funds), which lead or co-lead Series A financings in the range of $10–50M and participate in select Series B and growth-stage rounds. The strategy spans biotechnology, medtech, digital health, and life sciences tools/services, with a data-driven focus on advancing differentiated technologies from preclinical stage through clinical proof-of-concept across North America.

Notable quotes

We have been impressed with the execution of the PXV Fund strategy and how quickly we found quality opportunities for investment. To further strengthen our efforts, Chris has successfully expanded the Xontogeny team to serve as Perceptive's early-stage venture arm, which is fully integrated with the Perceptive investment team.

Adam Stone · BusinessWire – Perceptive Advisors Closes $515M PXV Fund II announcement · 2021-05-12

We're helping founders build companies around life-saving technologies while showing that capital can be deployed more efficiently to benefit both founders and investors.

Chris Garabedian · Xontogeny press release – Launch of Several New Early-Stage Portfolio Companies · 2021-05-12

The PXV Fund will benefit from the Xontogeny model and its ability to seed finance, incubate and de-risk early-stage technologies by providing proven operational expertise, a more capital-efficient structure, and a strong partnership in advising and mentoring entrepreneurs and scientific founders.

Chris Garabedian · Perceptive Advisors Closes Inaugural $210M PXV Fund announcement · 2019-12-10

Team

Chris Garabedian

Chairman & CEO

Bio/PharmaHealthtechDeep Tech

Fred Callori

Senior Partner

Bio/PharmaDeep Tech

Gianna Hoffman-Luca, Ph.D.

Partner

Bio/PharmaHealthtech

Takeru Furuya, Ph.D.

Principal

Bio/PharmaDeep Tech

Thien Nguyen, Ph.D.

Senior Associate

Bio/Pharma

Jayanth Batchu

Senior Associate / EIR

Bio/PharmaHealthtech

Recent investments

CompanyRoundSizeDate
Crystalys TherapeuticsSeries A$205m2025-09-30
Merida BiosciencesSeries A$121m2025-04-08
Marea TherapeuticsSeries A$190m2024-06-18
NeurosterixSeries A$63m2024-04-03
CARGO TherapeuticsSeries A$200m2023-03-01
Apogee TherapeuticsSeries B$169m2023-01-15
TORL BioTherapeuticsSeries B$158m2023-04-13
Avalyn PharmaSeries C$175m2023-09-27
Forge BiologicsSeries B$120m2021-04-29
Galvanize TherapeuticsSeries C$100m2025-09-03

Frequent co-investors

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